May December tells the story of Gracie (Julianne Moore) and her husband Joe (Charles Melton), who is 23 years younger than her. Their relationship began when Joe was still 13 years old, causing a scandal in the newspapers. Twenty years after their romance made headlines, the couple is preparing for their twins to start high school. However, their lives are turned upside down when actress Elizabeth Berry (Natalie Portman) comes to study Gracie for a film role. Family dynamics unfold as Joe realizes he has lost his youth.