Based on the comics by Aaron Blabey, The Mean Guys follows a group of thieving animals and their shenanigans. Mr. Wolf, Ms. Tarantula, Mr. Shark, Mr. Piranha and Mr. Cobras have always been seen as evil, misfits and scare everyone who sees them. They have a long criminal history, stealing whatever they want however they want. In one of his heist plans at a gala event, Mr. Lobo realizes that they can be good, or rather, that people can see them as good animals. Being caught by the police after an unsuccessful plan, the group of thieves decide to pretend to be nice so that the police don’t follow them and they don’t get sent to prison. They end up accepting Professor Marmalade’s proposal to help him recover guinea pigs that are being used for testing in a company. Will the group’s farce hold up? Or will they finally be the good guys in history?