Madame Web shows the origin story of the title character, played by Dakota Johnson. In the plot, Cassandra Webb leads an ordinary life working as a paramedic in Manhattan until, one day, she discovers that she has the ability to predict the future. One of her visions ends up leading Cassandra to young Julia Carpenter (Sydney Sweeney), Anya Corazon (Isabela Merced) and Mattie Franklin (Celeste O’Connor). It doesn’t take long for the four of them to understand that, together, they are destined for something very powerful.