In Smile, everything in the life of Dr. Rose Cotter (Sosie Bacon) changes, after a patient dies brutally in front of her, and she witnesses the bizarre and traumatic incident in the office. From then on, she begins to experience frightening occurrences that she cannot explain, but which are somehow related to the death she witnessed. To understand the phenomenon that won’t leave her head, the Doctor will look for answers, even if evil is already chasing her, and all she wants most is to escape. Rose will go to extreme lengths, with the aim of unraveling and combating the unknown evil that has begun to affect her life and everyone around her. Every day more immersed in this web of frightening events, to survive, she must face the disturbing situation that presents herself, and try to escape her new and horrible reality.